Design of a high-performance non-linear gradient coil for diffusion weighted MRI of the breast.

Abstract Diffusion-weighted imaging (DWI) in the female breast is a magnetic resonance imaging (MRI) technique that complements clinical routine protocols, and that might provide an independent diagnostic value for specific clinical tasks in breast imaging. To further improve specificity of DWI in the breast, stronger and faster diffusion weighting is advantageous. Here, a dedicated gradient coil is designed, targeted at diffusion weighting in the female breast, with the peak gradient magnitude exceeding that of the current clinical MR scanners by an order of a magnitude. Design of application-tailored gradient coils in MRI has recently attracted increased attention. With the target application in mind, the gradient coil is designed on an irregularly shaped semi-open current-carrying surface. Due to the coil former closely fitting the non-spherical target region, non-linear encoding fields become particularly advantageous for achieving locally exceptionally high gradient strengths. As breast tissue has a predominantly isotropic cellular microstructure, the direction of the diffusion-weighting gradient may be allowed to vary within the target volume. However, due to the quadratic dependency of the b-factor on the gradient strength, variation of the gradient magnitude should be carefully controlled. To achieve the above design goals the corresponding multi-objective optimization problem is reformulated as a constrained optimization, allowing for flexible and precise control of the coil properties. A novel constraint is proposed, limiting gradient magnitude variation within every slice while allowing for variations in both the direction of the gradient within the slice and the magnitude across the slices. These innovations enable the design of a unilateral coil for diffusion weighting in the female breast with local gradient strengths exceeding 1 T/m with highly homogeneous diffusion weighting for imaging in the coronal slice orientation.