Resilience of the respiratory microbiome in controlled adult RSV challenge study.

Respiratory syncytial virus (RSV) is the commonest cause of acute lower respiratory tract infection (RTI) in infants, resulting in seasonal surges in hospital admissions [1]. In addition to its impact in childhood, RSV is increasingly recognised as a cause of morbidity and mortality in elderly persons [2]. The virus is highly contagious and regularly causes reinfections despite limited genetic diversity [3]. Safe and effective vaccines have so far proven elusive [2]. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Leah Cuthbertson has nothing to disclose. Conflict of interest: Phillip James has nothing to disclose. Conflict of interest: Maximillian S Habibi has nothing to disclose. Conflict of interest: Ryan S Thwaites has nothing to disclose. Conflict of interest: Allan Paras has nothing to disclose. Conflict of interest: Christopher Chiu has nothing to disclose. Conflict of interest: Peter J. M. Openshaw has nothing to disclose. Conflict of interest: William O.C. Cookson has nothing to disclose. Conflict of interest: Miriam F Moffatt has nothing to disclose.