Antibodies to Coxsackie B viruses and HLA in Japanese with juvenile-onset Type 1 (insulin-dependent) diabetes mellitus

One hundred and three patients with juvenile-onset Type 1 (insulin-dependent) diabetes mellitus have been studied for evidence of previous Coxsackie B virus infection and compared with age- and sex-matched controls. Coxsackie B4 or B3 neutralization titre ⩾ 80 were more common among the patients than among the control subjects, but showed no association with HLA-B phenotypes.