Healing Effects of Iodine and Thyroid Hormone on Experimental Rickets

The Steenbock 2965 diet has been regarded as a standard rachitogenic diet, but in 1961 Shimazaki and Yagi pointed out that this diet is also deficient in iodine, and the rachitic findings produced on this diet could be ameliorated with potassium iodide (KI). Further, in 1984 Shimazaki et al. (1) found that triiodothyronine (T3) is more effective in this respect than iodine and even vitamin D (v.D). In this study, to determine the physiological basis of this beneficial effect, the actions of T3 on mineral metabolism have been investigated and compared with those of v.D.