Prolonged Survival of Human Skin Xenografts on Antithymocyte Serum-Treated Mice: Failure to Produce Verrucae by Inoculation with Extracts of Human Warts

This report describes an experimental system whereby human skin was grafted to immunosuppressed mice, thus avoiding the restrictions imposed by the use of human subjects or tissue cultures. Grafts remained in good condition for the subsequent life of the animal, as long as eight months. The human skin xenografts were inoculated with an extract of verrucae vulgaris, but no warts developed during the period of observation.