Copper-Catalyzed Regio and Diastereoselective Three Component C—N, C—C and C—O Bond Forming Reaction: Oxidative sp3 C—H Functionalization.

21 Tetrahydroisoquinoline derivatives of type (IV) or (VII) are prepared by a one-pot three-component reaction comprising the formation of a C—N, a C—C and a C—O bond.