3 In-depth proteomic analyses of ovarian cancer cell line exosomes reveals 4 differential enrichment of functional categories compared

Molecular communication between cancer cells and its stromal microenvironment is a key factor for can27 cer progression. Alongside classic secretory pathways, it has recently been proposed that small membra28 nous vesicles are alternative mediators of intercellular communication. Exosomes carry an effector-rich 29 proteome with the ability to modulate various functional properties of the recipient cell. In this study, 30 exosomes isolated from four epithelial ovarian cancer cell lines (OVCAR3, OVCAR433, OVCAR5 and