Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

Matthew Zimmerman,Stacey L. McDonald,Hsin Pin Ho-Liang,Patrick Porubsky,Quyen Nguyen,Cameron W. Pharr,Andrew J. Perkowski,Robert A. Smith,Frank J. Schoenen,Ben Gold,David Zhang,Carl Nathan,Véronique Dartois,Jeffrey Aubé

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

2019

Matthew Zimmerman
Stacey L. McDonald
Hsin Pin Ho-Liang
Patrick Porubsky
Quyen Nguyen
Cameron W. Pharr
Andrew J. Perkowski
Robert A. Smith
Frank J. Schoenen
Ben Gold
David Zhang
Carl Nathan
Véronique Dartois
Jeffrey Aubé

A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.

Keywords:

Biochemistry
Moiety
Cleavage (embryo)
Biology
Cephalosporin

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