Adverse Local Tissue Reaction Due to Mechanically-Assisted Crevice Corrosion Presenting as Late Instability Following Metal-on-Polyethylene Total Hip Arthroplasty

Abstract Introduction Mechanically-assisted crevice corrosion (MACC) at modular junctions can cause a spectrum of adverse local tissue reactions (ALTR) in patients who have undergone total hip arthroplasty (THA). The purpose of this study is to describe the presentation, treatments, and related complications of a cohort of patients presenting with late instability following metal-on-polyethylene THA due to underlying MACC and ALTR. Methods This multicenter retrospective case series presents seventeen patients (12 women, mean age 62.6, range 42 - 73) presenting with late instability secondary to ALTR and MACC. All patients had a metal (CoCr)-on-polyethylene bearing surface. Patients experienced a mean 2.7 dislocations (range, 1 to 6) at mean 4.3 years (range, 0.4 - 17.0) following their index surgery. Serum metal levels (n=12) demonstrated a greater elevation of cobalt (mean 6.9, range 0.13 – 20.88 ng/mL) than chromium (mean 1.9, range 0.13 – 3.23ng/mL). Results Patients were revised for instability at a mean of 6.8 years (range, 2.1 to 19.4) following their index surgery. ALTR was encountered in every case and the modular head-neck junction demonstrated visible corrosion. An exchange of the CoCr head to a ceramic head with a titanium sleeve and placement of a constrained liner was performed for a majority of patients (n=15, 88.2%). Five patients (29.4%) had complications postoperatively including peroneal palsy (n=2), periprosthetic joint infection (n=2), and ALTR recurrence (n=1). Conclusions Recurrent instability in the setting of otherwise well-positioned THA components and without another obvious cause should raise concern for ALTR as a potential underlying etiology.