The mitochondrial calcium uniporter: a new therapeutic target for Parkinson’s disease-related cardiac dysfunctions?

In 1817, the London surgeon and pharmacist James Parkinson published a 66-page-long booklet entitled “An Essay on the Shaking Palsy”, which contains the first detailed, clinical description of the shaking palsy, or “paralysis agitans”, which is currently known as Parkinson’s disease (PD) (). Two important facts James Parkinson probably did not consider at that time include the scientific progress of neuroscience over the past two centuries and the changes in the world’s population aging since then (). In fact, the [...]