Inappropriate combinations of antiretroviral drugs

: At present 19 antiretroviral drugs are available, which offer together 969 possible triple-combinations. Only a few combinations, mainly of nucleoside inhibitors of reverse transcriptase, are contraindicated due to undesirable interactions, which may negatively influence the treatment efficacy or increase toxicity. With raising number of antiretroviral drugs there must also be paid more attention to possible interactions of these drugs.