New preparation of 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidine-5-yl)-n,n-dimethylacetamide

PURPOSE: A novel method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidine-5-yl)-N,N-dimethylacetamide is provided to suppress urea by-product production and t improve production yield. CONSTITUTION: A method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidine-5-yl)-N,N-dimethylacetamide of chemical formula 1 comprises: a step of reacting a compound of chemical formula 3 with 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidine-5-yl)-acetic acid of chemical formula 2 under the presence of base; and a step of reacting with dimethylacmine. The base is triethyl amine, trimethyl amine, triisopropyl amine or diisopropyl ethyl amine. The compound of chemical formula 3 is ethyl chloroformate.