Is cushing's syndrome remission associated with diabetes regression? Analysis of a retrospective cohort of 108 patients with cushing's disease

Background Diabetes mellitus (DM) is a common comorbidity of Cushing’s syndrome (CS) and plays an important role in morbidity and death of patients with uncontrolled hypercortisolism. Some authors define DM in CS as a ‘specific type of diabetes secondary to endocrinopathy’, although others judge it as a classical form of type 2 DM. Glucocorticoid (GC) excess causes pancreatic beta cell dysfunction and insulin resistance, which correlates with hypercortisolism level. If Cushing’s disease (CD) remission implicates on DM resolution remains unclear.