Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart

Holger Lörchner,Jochen Pöling,Praveen Gajawada,Yunlong Hou,Viktoria Polyakova,Sawa Kostin,Juan M. Adrian-Segarra,Thomas Boettger,Astrid Wietelmann,H. Warnecke,Manfred Richter,Thomas Kubin,Thomas Braun

Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart

2015

Holger Lörchner
Jochen Pöling
Praveen Gajawada
Yunlong Hou
Viktoria Polyakova
Sawa Kostin
Juan M. Adrian-Segarra
Thomas Boettger
Astrid Wietelmann
H. Warnecke
Manfred Richter
Thomas Kubin
Thomas Braun

After myocardial infarction, dedifferentiated cardiomyocytes secrete the protein Reg3β, thereby recruiting macrophages required for neutrophil clearance and myocardial healing.

Keywords:

Immunology
Neutrophil clearance
Myocardial infarction
Secretion
Medicine
Cardiology
ischemic heart
Internal medicine

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