Bispohosphonates in the Treatment of Breast Cancer

Janni: We have very limited research to speculate on a solid basis, we might never know. Based on the data on disseminated tumor cells in bone marrow, we can presume that the bone marrow is host to dormant tumor cells for a long time. Changes in the microenvironment by bisphosphosphonates, inhibiting the tumor cells’ ability to proliferate, might play a stronger role in an estrogen deprivation status.