Insulin-like Growth Factor Initiates Hepatocellular Carcinoma in Chronic Hepatitis C Virus Patients through Induction of Long Non-coding Ribonucleic Acids AF085935: Role of LncRNA AF085935 in HCC development

Abstract HCV is the most commonly occurring hepatic infection worldwide.  Chronic HCV infection usually complicated with cirrhosis and even HCC with significant morbidity and mortality. The aim of this study to clarify the molecular mechanism by which HCV can induce HCC and identify a new diagnostic marker for early detection of HCC. Methods: 180 participating subject were divided in to three groups. Group 1: 60 healthy individuals (controls).  Group 2: 60 HCV infected patients. Group 3:  60 HCV patients developed HCC. Serum IGF, FOXO and LncRNA AF085935 were evaluated. Results:  Serum IGF was significantly elevated in HCV and HCC patients, while FOXO and LncRNA AF085935 were significantly up regulated in HCC. IGF significantly correlated with and LncRNA AF085935. Conclusion:  HCV can induce IGF with subsequent induction of   LncRNA AF085935 and FOXO. Key word: HCV, HCC, IGF, FOXO and LncRNA AF085935.