From more testing to smart testing: data-guided SARS-CoV-2 testing choices

We present an in-depth analysis of data from drive through testing stations using rapid antigen detection tests (RDTs), RT-PCR and virus culture, to assess the ability of RDTs to detect infectious cases. We show that the detection limits of five commercially available RDTs differ considerably, impacting the translation into the detection of infectious cases. We recommend careful fit-for-purpose testing before implementation of antigen RDTs in routine testing algorithms as part of the COVID-19 response.