Эндотелиальная дисфункция при хронической болезни почек у детей

The changes in serum concentrations ofendothelin-1 (ET-1) and ICAM-1 were investigated in 138 children with chronic kidney disease (CKD) in stage 1 and 2. For values of glomerular filtration rate (GFR) > 90 ml/min a reversible increase in ET-1 and ICAM-1 level in children with active as steroid-resistant as steroid-dependent nephrotic syndrome has been shown. In patients with prognostically unfavorable nonimmune glomerulopathies and polycystic kidney disease in the absence of pronounced proteinuria and hypertension levels of the studied compounds were not significantly different from seen in the reference group. With decreasing GFR below 90 ml/min, the highest indicators of serum ET-1 and ICAM-1 concentrations were detected as in the immune, and in nonimmune glomerulopathies. This indicates a high degree of participation of endothelial disorders in CKD progression, which gives reason to consider the use of indicators of endothelial dysfunction as potential markers of development of nephrosclerosis in children.