Neonatal diabetes mellitus: chromosomal analysis in transient and permanent cases.

Abstract Objectives: To describe a large cohort of patients with transient neonatal diabetes mellitus (TNDM) and permanent neonatal diabetes mellitus (PNDM), and to investigate whether chromosome 6 analysis helps to distinguish TNDM from PNDM. Study design: Patients with TNDM (n = 29) (insulin therapy for Results: Although patients with PNDM were less likely to have had intrauterine growth restriction (36% vs 74% for TNDM, P Conclusion: When present, a chromosome 6 abnormality is strongly in favor of the "transient" form of the disease. (J Pediatr 2002;141:483-9)