Laboratory guidelines for the diagnosis of patients with cryoglobulinemic syndrome

Abstract Cryoglobulinemic syndromes include a collection of manifestations that are found in various diseases and that share a pathophysiological mechanism: cryoglobulin deposit in vascular beds. For these syndromes, the presence of cryoglobulins is a diagnostic criterion, and their correct detection and characterization are therefore essential. The Immunochemistry Group of the Spanish Society of Immunology conducted a comprehensive clinical and methodological review, due to the interlaboratory heterogeneity in techniques, with the objective of providing a useful and effective tool for diagnosing cryoglobulinemic syndromes.