Response of Cercopithecus aethiops to cholera vibrio lipopolysaccharide and psychological stress

Abstract 5 African green monkeys were exposed to mental stress for 2 weeks, during which they were immunized with Watanabe's lipopolysaccharide antigen prepared from an El Tor vibrio. 5 other animals were vaccinated with the same agent but were not exposed to stress. The El Tor haemolysin-inhibitory and the vibriocidal activities of the sera of the monkeys in both groups did not show significant differences, and the formation of agglutinins and coproantibodies, and the capability of the serum to neutralize the toxigenicity of the vibrios, in animals under stress, developed more slowly than in the control group. C. aethiops proved a feasible experimental animal for the study of antibody responses after the injection of a vibrio lipopolysaccharide.