Long term culture of normal skin to test the efficacyof a hydroxy acid-containing cream

Alpha-hydroxy acids (AHAs) applied topically at low concentrations, are now well-known to reduce the thickness of hyperkeratotic stratum corneum by reducing corneocyte cohesion at lower levels of the stratum corneum, increasing viable epidermal thickness and consequently thickening both the epidermal and dermal compartments of treated skin [1-3]. They have been shown to increase dermal glycosaminoglycans and thus counteract the [...]