Advance on Applications of Microwave Technique in Palladium- Cat- alyzed Suzuki-Miyaura Cross-Coupling Reaction

Compared with conventional heating, microwave heating is one of the most useful tools in organic synthesis be- cause of its obviously advantages of fast heating, thermal efficiency, saving energy, clean, and easy operation. Palladium cata- lyzed Suzuki-Miyaura cross-coupling reaction could tolerate a broad range of functional groups with high stereoselectivity to provide a mild method in preparation of kinds of substituted biaryls. In this paper, the recent research results about the micro- wave technique applied in Suzuki-Miyaura cross-coupling reaction are reviewed, involving various reaction systems. The ap- plications of the methodology on the synthesis of natural products and bioactive molecules have also been introduced. Keywords microwave technique; palladium; Suzuki-Miyaura cross-coupling reaction; catalyze