Variations in Soil Alter Availability of Carlinoside:An Anti-Hepatitic Compound from Cajanus cajan (LINN.) Leaves

Agro-climatic factors largely regulate expression of phenolic compounds in plants. Carlinoside, a flavone glycoside, is known to eliminate bilirubin accumulation in rat liver. We cultivated Cajanus cajan uniformly in two different soil types - alluvial (AL) and laterite (LA). The climatic attributes and soil physicochemical properties of the two localities were significantly different from each other. Carlinoside, phenol and flavonoid concentrations were higher in plants grown in AL than in LA soils. We recorded higher UGT1A1 expression in liver hepatoma cell line HepG2 and rats treated with plant extracts from AL compared to LA.