The enigma of acute worsening after a latent interval in post-operative patients of craniovertebral junction instability.

Abstract Objective For reasons that are poorly understood and still undocumented, few patients of craniovertebral junction (CVJ) anomalies with instability/atlantoaxial dislocation (AAD) in our practice have been seen to suffer unprecedented acute neurological deterioration with respiratory compromise about 48–72 h post-surgery. This has been specifically observed after an uneventful, stable clinical condition in the immediate postoperative period. This study attempts to elucidate the factors and outcomes related to such latent worsening. Patients and methods The 4-year surgical data of 268-patients with CVJ instability (AAD/basilar-invagination) who underwent C1-C2 fixation were retrospectively studied. The relevant factors of 17 patients who showed such deterioration were compared with that of the remaining in a multivariate model. Results Seventeen patients had acute neurological worsening with respiratory arrest after a latent period. Ten improved at follow-up. Contrary to the general expectation, poor preoperative neurological score or severe dislocation that needed considerable manipulation did not influence such worsening. Dural injury in patients with associated Chiari malformation and vertebral arterial (VA) injury emerged as independent factors (p  Conclusions We report our management and outcomes of a unique subset of AAD with neurological worsening in the postoperative period after 48–72 h. Such a subgroup was not previously identified in literature. Dural lacerations in AAD with Chiari, and VA injury seem to predispose to such complications and should be prevented at best. Close observation, and caution regarding early extubation (