A prospective study assessing the value of geriatric assessment in elderly patients with stage III NSCLC for concurrent chemoradiation.

8509Background: Concurrent chemoradiotherapy (cCRT) has proven to increase survival in elderly patients (p) with unresectable stage III NSCLC, but it is not yet accepted as standard of care. The geriatric assessment (GA) might help to characterize p who benefit from cCRT. Methods: Elderly p ( ≥ 74 years) with stage III NSCLC underwent GA, including validated instruments to assess comorbidity, polypharmacy, functional status, geriatric syndromes (GS), mood, cognition and Vulnerable Elders Survey (VES-13). P were classified according to the GA into fit and medium fit who were deemed candidates for antitumoral treatment and unfit patients received best supportive care. Clinical, GA and follow-up data were prospectively collected. Median overall survival (mOS) was calculated using Kaplan-Meier method. Results: From 07/2008 to 11/2015, 73 elderly p with unresectable stage III NSCLC were identified. Median age: 79.5 (74-86); gender (M/F): 88%/12%; histology (SCC/AD/NOS): 58%/22%/20%; stage (IIIA/IIIB): 67%/33%;...