Abstract 3988: Identification of miR-132 and miR-290-3p as putative tumor and metastasis suppressor microRNAs in breast cancer

Several microRNAs (miRNAs) have been classified as regulators of breast cancer metastasis [1], yet additional unidentified miRNAs may also exist that regulate metastasis. Most interesting, we propose that germline genetic changes may exist which create a predisposition towards developing breast cancer metastasis through the dysregulation of miRNAs. Thus, to identify novel miRNAs associated with a germline predisposition towards breast cancer metastasis, highly metastatic FVB/N-TgN (MMTV-PyMT) mice were crossed with 25 AKXD RI (AKR/J × DBA/2J) strains to produce F1 progeny displaying primary mammary tumors with varying degrees of pulmonary metastasis. The miRNA expression levels within all mammary tumors were evaluated using a miRNA microarray and correlated with the metastatic index for each strain. The analysis produced 27 candidate miRNAs possessing a significant p-value (p 1. Hurst, D.R., M.D. Edmonds, and D.R. Welch, Metastamir: the field of metastasis-regulatory microRNA is spreading. Cancer Res, 2009. 69(19): p. 7495-8. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3988. doi:10.1158/1538-7445.AM2011-3988