Reply to Sadaba
2009
We very much appreciate the comments by Sadaba [1] and he is correct to highlight the importance of the rho-kinase pathway. From the data presented in our paper [2] and that from earlier studies on the actions of phenoxybenzamine [3,4] it is clear that should an irreversible inhibitor of rhokinase become available it would represent an ideal candidate for the topical treatment of arterial bypass grafts.
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