[Significance of detection of biomarker fecal bile acids in the diagnosis and treatment of childhood Henoch-Schönlein purpura].

To investigate the changes and clinical significance of biomarker fecal bile acids (BA) in children with Henoch-Schonlein purpura (HSP).Nineteen children with HSP and twenty-seven healthy children were enrolled in this study. The stool samples were obtained at the acute and remission phases. Fecal BA levels were measured by high performance liquid chromatography mass spectrometry (HPLC-MS).The fecal cholic acid level in the HSP remission group was significantly higher than in the HSP acute group and the healthy control group (P 0.05).Fecal secondary colonic bile acids, deoxycholic acid and lithocholic acid, are in decrease in children with HSP at the acute stage, which may be involved in the pathogenesis and treatment outcomes of HSP.