Experimental Hypervitaminosis D

Summary1. Rats given massive doses of vit. D2 show increased serum levels of calcium and seromucoid (a mucoprotein), calcareous deposition in the heart, kidneys, and blood vessels, and accumulation of polysaccharides in the same locations. Myocarditis, unassociated with deposition of calcium as assessed histologically, was observed. 2. Calcium deposits occur in a matrix containing acid mucopolysaccharides.