Антиатеросклеротические свойства 4-(2,6-диметилгептил)и 4-(2,6,10-триметилундецил)бензойной кислоты и их амидов

Two amides with polyol-rich moieties and two other analogs with N-(β-aminoethyl) groups, all derived from 4-(2,6-dimethylheptyl)benzoic acid (I), and two polyol amides derived from 4-(2,6,10-trimetylundecyl)benzoic acid (II) were synthesized and tested for antiatherosclerotic activity in vitro . None of the amides prevented excessive accumulation of cholesterol in the culture of smooth muscle cells (SMCs) raised from aorta sclerotic plaque, although polyol amides from acid I inhibited protein synthesis in this cell culture. In human liver homogenates (HLHs) all amides obtained from acid I accelerated the cholesterol esterase-catalyzed hydrolysis of cholesteryl palmitate. Acid I displays antiatherosclerotic effects in both SMC and HLH assays, while acid II and its amides proved ineffective in either of these test systems.