Nuclear Factor κB Inhibition by Dibenzoylmethane Derivatives

We established stable HeLa transformants with reporter genes containing nuclear factor (NF)-κB response elements to measure NF-κB inhibition. Tumor necrosis factor (TNF)-α treatment induced a 6-fold activation of NF-κB in HeLaNF-κB-3 cells. Three chloro-derivatives of fourteen dibenzoylmethane derivatives inhibited NF-κB activity.