DEVLOPMENT AND IN VITROEVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF FAMOTIDINE

The present study reports the development and in vitroevaluation of gastro retentive floating tablets of Famotidine. The formulations were developed using cellulose derivatives such as HPMC K4M, HPMC K15M and HPMC K100M in different ratios with gas generating agents and other excipients by wet granulation technique. The formulations were subjected to various evaluation parameters in vitro, viz ., hardness, friability, uniformity of drug content, in vitrofloating studies , in vitro dissolution studies, allthe formulations were good in appearance and showed better physical and mechanical properties. Formulation M15 containing HPMC K4M 80 mg, Sodium bicarbonate 40 mg, 30 mg citric acid and PVP K30 10mg was found to be the best formulation in terms of drug release and in vitrobuoyancy time and was subjected to st ability studies and IR spectroscopy .The results indicate that the formulation was stable and there was no chemical interaction between the polymer and the drug.