Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis

Dinesh K. Sivakolundu,Kathryn L. West,Gayathri Batchalli Maruthy,Mark D. Zuppichini,Monroe P. Turner,Dema Abdelkarim,Yuguang Zhao,Dylan Nguyen,Jeffrey S. Spence,Hanzhang Lu,Darin T. Okuda,Bart Rypma

Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis

2019

Dinesh K. Sivakolundu
Kathryn L. West
Gayathri Batchalli Maruthy
Mark D. Zuppichini
Monroe P. Turner
Dema Abdelkarim
Yuguang Zhao
Dylan Nguyen
Jeffrey S. Spence
Hanzhang Lu
Darin T. Okuda
Bart Rypma

Background:Cognitive slowing occurs in ~70% of multiple sclerosis (MS) patients. The pathophysiology of this slowing is unknown. Neurovascular coupling, acute localized blood flow increases followi...

Keywords:

Pathophysiology
Pathology
Blood flow
Neurovascular bundle
Medicine
Internal medicine
Multiple sclerosis
Cardiology
Cognition
neurovascular coupling
vascular reactivity

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