Surgical Treatment Of Advanced Medication-Related Osteonecrosis Of The Jaws: Comparison Of Soft Tissue Closure Techniques And Evaluation Of Side Effects

Summary Purpose The aim of the study was to evaluate the surgical outcome of patients with advanced medication-related osteonecrosis of the jaw (MRONJ) treated with different flaps for soft tissue closure. Methods Only MRONJ stage III patients with a minimum follow-up of 6 months were included in our prospective study. The soft tissue closure techniques were: Mylohyoid Muscle Flap, Buccal Fat Flap and mucoperiosteal flap alone. Potential risk factors and surgical side effects were analyzed. Results Relapses occurred in 12 of 44 included cases and 38 reached mucosal integrity within the follow-up. Cases treated with the muscle or fat flap showed better results regarding the recurrence rate (p Conclusion Patients with MRONJ stage III undergoing surgery benefit from extensive soft tissue closure.