Inducing nonsense suppression by targeted pseudouridylation

), which allows Ψ to be involved in inter- or intra-molecular hydrogen bonding through a water bridge. The water-bridged intramolecular hydrogen-bonding network is formed between the water molecule and the N1 imino-hydrogen and the 5′ phosphate oxygen of Ψ as well as the phosphate oxygen of the 5′ preceding nucleotide