Ocular hypotensive agent

Object of the present invention is to provide an ocular hypotensive agent as glaucoma, ocular hypertension and other prophylactic or therapeutic agent, comprising a compound of formula (1): wherein A is a methylene group, an ethylene group or an oxygen atom, n is an integer of 3 or 4, R is optionally substituted phenyl, optionally substituted 2-pyridyl, optionally substituted 2-pyrimidinyl, and bicyclic solid line with dotted lines means a single bond or is double bond.