Effect of pyrogenes on the activity and isoenzyne spectrum of lactate dehydrogenase in tissues and blood serum of guinea pigs

It is established that 2,4 DNP effect produces no changes in the total activity of lactate dehydrogenase (LDH, EC 1.1.2.3) in the heart, liver and blood serum of guinea pigs. Under the effect of lipopolysaccharide obyained from Bact. alkaligenes faecalis it increases in the liver and heart. A change in the isoenzymic spectrum is characterized bt a decrease in the LDA3, LDH4, LDH5 activity in the blood serum, an increase in the activity LDH1, LDH2 and a decrease in the LDH4, LDH5 in the myocardium, disappearance of LDH, in the liver under the effect of bacterial lipopolysaccharide. Under the effect of 2.4 DNP the activity of LDH3 in the liver increases and that of LDH3 DECREASES.