Optimal local hypothermia regimen in the experimental resection of the single kidney

: The morphological and functional changes of the single kidney were investigated in experiment on 133 dogs after removal of 45--50% of its tissue. Resection of the single kidney under normothermal conditions was established to result in the animal's death within 1--14 days due to acute renal insufficiency. The operation executed under conditions of cooling to 25 degrees C is of high risk. Resection under 5 degrees C hypothermia fails to cause an acute renal insufficiency but considerably disturbs the renal function. The use of local hypothermia to 15 degrees C in resection of the single kidney gives the optimal temperature regimen since it prevents the development of acute renal insufficiency and the compensatory-restorative processes in the kidney can develop successfully.