Preparation method of organic-inorganic hybrid monolithic capillary column

The invention provides a preparation method of an organic-inorganic hybrid monolithic capillary column. According to the method, a silicane precursor, a dispersant and a catalyst are mixed, and are violently stirred under an ice water bath until the mixture is transparent and viscous; an organic functional monomer, a pore forming agent and an initiator are added to the mixture, the resulting mixture is completely dissolved under ultrasound at a temperature of 0 to 4 DEG C, the dissolved mixture is injected into a vinyl-modified quartz capillary, and a monolithic column is obtained after processing. The hybrid monolithic column possesses the advantages of organic monolithic columns and inorganic monolithic columns, and is suitable for separating or enriching micro-molecules, nucleotide, polysaccharide and glycoprotein which contain cis-1,2-glycol structures.