Influence of δ-opioid receptor in the central nervous system

The delta-opioid receptor (DOR), which is a classic analgesic drug widely existed in the central system and peripheral system, is a kind of inhibitory G-protein coupled receptor with seven transmembrane regions. In addition to pain modulation, the opioid receptors are involved in various physiological and pathological activities through gene or cytokines. This review addresses the influence and possible mechanisms of the delta-opioid receptor in ischemic brain injury, analgesia, anti-anxiety and depression, learning and memory, and Parkinson's disease. Key words: Receptors, opioid, delta; Central nervous system; Central nervous system diseases; Review