Changes in Serum Levels of Creatol and Methylguanidine in Renal Injury Induced by Lipid Peroxide Produced by Vitamin E Deficiency and GSH Depletion in Rats

Hisashi Ozasa,Tomoe Watanabe,Ko Nakamura,Yasutsugu Fukunaga,Kazuharu Ienaga,Kiyokazu Hagiwara

Changes in Serum Levels of Creatol and Methylguanidine in Renal Injury Induced by Lipid Peroxide Produced by Vitamin E Deficiency and GSH Depletion in Rats

1997

Hisashi Ozasa
Tomoe Watanabe
Ko Nakamura
Yasutsugu Fukunaga
Kazuharu Ienaga
Kiyokazu Hagiwara

A novel creatinine metabolite, creatol (5-hydroxycreatinine), is a key precursor in the synthesis of the uremic toxin methylguanidine (MG). Creatinine is converted to creatol within the mammalian body

Keywords:

Renal function
Creatinine
Vitamin E
Methylguanidine
Endocrinology
Vitamin E deficiency
Glutathione
Internal medicine
Metabolite
Toxin
Medicine
lipid peroxide

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