A randomized comparative study of topical versus intravenous tranexamic acid administration in enhanced recovery after surgery (ERAS) total knee replacement.

Abstract Background The aim of this study was to compare the topical to IV tranexamic acid (TXA) administration of the same dose, given at the same time in patients who underwent TKR using an enhanced recovery after surgery (ERAS) regime. Methods Ninety patients were randomized in control group, and IV and topical application groups received 1 g TXA. Results Blood loss and transfusion requirements in control group were statistically higher compared to both TXA groups ( p Conclusions TXA reduced significantly the blood loss and the need for transfusion in ERAS primary unilateral TKR.