Abstract 15044: Risk of Myocardial Infarction in Carriers of Familial Hypercholesterolemia Mutations is Modified by Common Variant Genetic Background or Adherence to a Healthy Lifestyle

Akl C. Fahed,Minxian Wang,Mark Chaffin,Alexander G. Bick,Candace Patterson,Pradeep Natarajan,Matthew S. Lebo,Puneet Batra,Kenney Ng,Patrick T. Ellinor,Anthony A. Philippakis,Sekar Kathiresan,Amit Khera

Abstract 15044: Risk of Myocardial Infarction in Carriers of Familial Hypercholesterolemia Mutations is Modified by Common Variant Genetic Background or Adherence to a Healthy Lifestyle

2019

Akl C. Fahed
Minxian Wang
Mark Chaffin
Alexander G. Bick
Candace Patterson
Pradeep Natarajan
Matthew S. Lebo
Puneet Batra
Kenney Ng
Patrick T. Ellinor
Anthony A. Philippakis
Sekar Kathiresan
Amit Khera

Background: Recent genetic studies have highlighted ‘incomplete penetrance’ of DNA sequence variants related to familial hypercholesterolemia mutations - although carriers on average have a three-f...

Keywords:

Diabetes mellitus
Medicine
gene mutation
Familial hypercholesterolemia
Hyperlipidemia
DNA sequencing
Cardiology
Internal medicine
Bioinformatics
Penetrance
Genomics
Myocardial infarction

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