Relationship between Matrix metalloproteinase-9 polymorphism and acute coronary syndrome

Abstract Objective To investigate the relationship of Matrix metalloproteinase-9 polymorphism to acute coronary syndrome and its affect on the severity of coronary artery disease. Methods By means of polymerase chain reaction (PCR) and restriction fragment length polymorphism, Genotypes of 245 patients with acute coronary syndrome (ACS) and 205 healthy subjects were tested. Genotypes displaying C-1562T functional promoter polymorphism (of the MMP-9 gene) were determined. The relationship between the polymorphism of the MMP-9 gene and ACS and the severity of coronary vessels diseased was analyzed. Results The frequency of C/ T plus T/ T genotypes and T allele in patients with ACS was significantly higher than that in healthy subjects (22.1%vs12.7 % and 11.4 %vs6.6% respectively). But they were not associated with the number of coronary arteries diseased. Conclusion The MMP-9 polymorphism may be susceptible to ACS. But there was not significant difference between the AMI and UAP subgroups