A possible role for B cells in COVID-19?: Lesson from patients with Agammaglobulinemia

Isabella Quinti,Vassilios Lougaris,Cinzia Milito,Francesco Cinetto,Antonio Pecoraro,Ivano Mezzaroma,Claudio Maria Mastroianni,Ombretta Turriziani,Maria Pia Bondioni,Matteo Filippini,Annarosa Soresina,Giuseppe Spadaro,Carlo Agostini,Rita Carsetti,Alessandro Plebani

A possible role for B cells in COVID-19?: Lesson from patients with Agammaglobulinemia

2020

Isabella Quinti
Vassilios Lougaris
Cinzia Milito
Francesco Cinetto
Antonio Pecoraro
Ivano Mezzaroma
Claudio Maria Mastroianni
Ombretta Turriziani
Maria Pia Bondioni
Matteo Filippini
Annarosa Soresina
Giuseppe Spadaro
Carlo Agostini
Rita Carsetti
Alessandro Plebani

Summary COVID-19 had a mild clinical course in patients with Agammaglobulinemia lacking B lymphocytes, whereas it developed aggressively in Common Variable Immune Deficiency. Our data offer mechanisms for possible therapeutic targets.

Keywords:

Common Variable Immune Deficiency
Coronavirus disease 2019
Immunology
Medicine
clinical course
Bruton's tyrosine kinase
severe acute respiratory syndrome coronavirus 2
2019 20 coronavirus outbreak
in patient
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