Primary Treatment of Small-To-Medium (<3cm) Sporadic Vestibular Schwannomas: A Systematic Review And Meta-Analysis on Long-Term Hearing Preservation And Tumor Control Rates For Microsurgery Versus Radiosurgery.

Background A meta-analysis of sporadic VS patients primarily treated with stereotactic radiosurgery (SRS) or microsurgery (MS) was performed, and hearing preservation outcome (HPO), tumor control (TC), and facial nerve dysfunction (FND) were analyzed. Methods A systematic review was conducted (Medline and Scopus database) for the period, January 2010 to June 2020 with appropriate MeSH. English language articles for small-to-medium sporadic VS ( Results Thirty-two studies met inclusion criteria: 10 (microsurgery); 23 (radiosurgery); (one comparative study included in both). HPO, at ∼65 months follow-up, were comparable between MS group (10 studies; 809 patients) and SRS group (23 studies; 1234 patients) (56% versus 59%, p=0.1527). TC, at ∼70 months follow-up, was significantly better in MS group (9 studies; 1635 patients) versus SRS group (19 studies; 2260 patients) (98% versus 92%, p Conclusion MS and SRS are comparable primary treatments for small ( 90%) were seen with both modalities; MS (98%) versus SRS (92%). The post-treatment FND was significantly less with SRS group (2%) versus MS group (10%).