Drug interaction of oral anticoagulants and dexamethasone, a nested case control study in the National COVID Cohort Collaborative (N3C)

We report on our use of the National COVID Cohort Collaborative (N3C) Data Enclave platform to examine the rate of thromboembolic events in COVID-19 patients exposed concomitantly to dexamethasone and a direct oral anticoagulant (DOAC), compared to those taking a DOAC alone. In this poster we will discuss the lessons we learned conducting this study which is the first drug-drug interaction (DDI) study to take place within the N3C Data Enclave.