Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death
2013
Two hybrid compounds comprising an antimetastatic ruthenium–arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.
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