Formulation and Development of In Situ Gelling System for Nasal Administration for Ondansetron Hydrochloride by Using Pluronic F-127

In the recent years one of the big problems with cancer chemotherapy is cancer induced nausea and vomiting (CINV). In the treatment of CINV the use of 5HT3 receptor antagonist is most popular. One of such 5HT3 antagonist is Ondansetron Hydrochloride. But Ondansetron has a low oral bioavailability along with a patient suffering from vomiting problem it is difficult to deliver the drug through oral route. So our objective is to prepare a in situ nasal gel of the Ondansetron using PF-127 as the thermoreversible polymer. We used HPMC E15 and Chitosan as the mucoadhesive polymer to increase the nasal residence time of the formulation. To increase the permeation we used Polyethylene Glycol 400 and Propylene glycol as the permeation enhancer.